Clinical Research & Case Studies

A comprehensive directory of scientific research and clinical evidence informing the Vivvira formulations.

Lactiplantibacillus plantarum HY7714

Clinical Studies

Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study.

J. Microbiol. Biotechnol. (2015). http://dx.doi.org/10.4014/jmb.1509.09021
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Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition.

PLOS ONE 15(4): e0231268 (2020). https://doi.org/10.1371/journal.pone.0231268
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In Vitro Studies

Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin–Gut Axis Communication.

Molecules 2021, 26, 1651. https://doi.org/10.3390/molecules26061651
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Lactobacillus plantarum HY7714 Restores TNF-α Induced Defects on Tight Junctions.

Prev. Nutr. Food Sci. 2019;24(1):64-69. https://doi.org/10.3746/pnf.2019.24.1.64
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Targeting Inflammation and Skin Aging via the Gut–Skin Axis: The Role of Lactiplantibacillus plantarum HY7714-Derived Extracellular Vesicles.

Microorganisms 2024, 12, 2466. https://doi.org/10.3390/microorganisms12122466
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In Vivo and In Vitro Combined Studies

Oral Administration of Lactobacillus plantarum HY7714 Protects Hairless Mouse Against Ultraviolet B-Induced Photoaging.

J. Microbiol. Biotechnol. (2014), 24(11), 1583–1591. http://dx.doi.org/10.4014/jmb.1406.06038
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Effect of Oral Administration of Lactobacillus plantarum HY7714 on Epidermal Hydration in Ultraviolet B-Irradiated Hairless Mice.

J. Microbiol. Biotechnol. (2014), 24(12), 1736–1743. http://dx.doi.org/10.4014/jmb.1408.08023
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Lactobacillus curvatus HY7601 + Lactiplantibacillus plantarum KY1032

Clinical Studies

Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on Overweight and the Gut Microbiota in Humans.

Nutrients, 14, 2484 (2022). https://doi.org/10.3390/nu14122484
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Supplementation with two probiotic strains reduced body adiposity and Lp-PLA2 activity in overweight subjects.

J. Funct. Foods, 19, 744–752 (2015). http://dx.doi.org/10.1016/j.jff.2015.10.006
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Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines.

Food & Function, 8, 250–261 (2017). https://doi.org/10.1039/c6fo00993j
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Supplementation reduces fasting triglycerides and enhances apolipoprotein A-V levels in subjects with hypertriglyceridemia.

Atherosclerosis, 241, 649–656 (2015). http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.030
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Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects.

Nutr. Metab. Cardiovasc. Dis., 25, 724–733 (2015). http://dx.doi.org/10.1016/j.numecd.2015.05.002
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In Vivo Studies - High-Fat Diet Models

A Mixture of Lactobacillus HY7601 and KY1032 Regulates Energy Metabolism in Adipose Tissue.

Nutrients, 16, 2570 (2024). https://doi.org/10.3390/nu16152570
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Effects of plant-based heat killed lactic acid bacteria on high-fat-induced obesity.

J. Agric. Food Res., 15, 100965 (2024). https://doi.org/10.1016/j.jafr.2024.100965
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Synergistic Effect of Lactobacillus Mixtures and Lagerstroemia speciosa Leaf Extract in Reducing Obesity.

Biology, 13, 1047 (2024). https://doi.org/10.3390/biology13121047
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Oral Administration with Cinnamomi Ramulus Extract Reduces Diet-Induced Obesity and Modulates Gut Microbiota.

Prev. Nutr. Food Sci., 24(2): 136-143 (2019). https://doi.org/10.3746/pnf.2019.24.2.136
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Triglyceride-Lowering Effects in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia.

J. Microbiol. Biotechnol., 26(3), 483–487 (2016). http://dx.doi.org/10.4014/jmb.1512.12018
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Supplementation in diet-induced obese mice is associated with gut microbial changes and reduction in obesity.

PLoS One, 8, e59470 (2013). https://doi.org/10.1371/journal.pone.0059470
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In Vivo Studies - Metabolic Syndrome Models

Dual probiotic strains suppress high fructose-induced metabolic syndrome.

World J Gastroenterol, 19(2): 274-283 (2013). http://dx.doi.org/10.3748/wjg.v19.i2.274
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Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and suppress diet-induced obesity.

Obesity, 21, 2571–2578 (2013). https://doi.org/10.1002/oby.20428
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In Vitro Studies - Cell Culture

The Inhibitory Effect of Lactobacillus plantarum KY1032 Cell Extract on the Adipogenesis of 3T3-L1 Cells.

J Med Food, 14(6): 670–675 (2011). https://doi.org/10.1089/jmf.2010.1355
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Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 cell extracts inhibit adipogenesis in 3T3-L1 and HepG2 cells.

J Med Food, 21(9): 876–886 (2018). https://doi.org/10.1089/jmf.2017.4157
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Lacticaseibacillus paracasei HY7017

Clinical Studies

The Immune-Boosting Potential of Lacticaseibacillus paracasei HY7017 in Adults with Suboptimal Immune Function.

Journal of Medical Food (2026). https://doi.org/10.1177/1096620X251384553
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In Vitro and In Vivo Studies

Characterization of Novel Lactobacillus paracasei HY7017 Capable of Improving Physiological Properties and Immune Enhancing Effects.

Fermentation 2021, 7(4), 238. https://doi.org/10.3390/fermentation7040238
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ButyraGen® (Tributyrin Complex)

Clinical Studies

Investigation of the tolerability and potential health benefits of a novel butyrate generating supplement in a pilot human study.

Nutrition and Healthy Aging, 9(1), 133-144 (2024). https://doi.org/10.3233/nha-240005
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A Novel Direct Butyrate Generator Reduces Belly Pain in a Randomized, Double-Blind, Placebo-Controlled Clinical Study.

Nutraceuticals, 5(2), 14 (2025). https://doi.org/10.3390/nutraceuticals5020014
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A Novel Butyrate Generator Helps Modulate the Gut-Brain Axis: A Randomized Double-Blind Placebo-Controlled Clinical Study.

NDS (2025). https://doi.org/10.2147/NDS.S565532
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Technical Documentation

ButyraGen® Clinical Study and Companion Technical White Paper: Tolerability and health benefits of novel butyrate.

NutriScience Innovations, LLC (2024).
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